Altering Lentiviral Tropism: Design and Implications of a Targeted Drug-Delivery System
نویسندگان
چکیده
A significant challenge in modern clinical medicine is that despite the existence of genetic therapies, lack of techniques to deliver them to the body remains a major roadblock. Viral vectors, benign vehicles for therapeutic delivery produced by removing the reproductive and virulence capacities of wild-type viruses, address this obstacle [1]. Unfortunately, if there is no naturally-occurring virus which infects a particular tissue it is nearly impossible to systematically deliver a therapy to that site. Moreover, the tropism of naturally-occurring viruses is often too broad or too narrow for delivery to both be effective and avoid off-target effects [2].
منابع مشابه
Design of the optimal magnetic field in application of functionalized CNT-based drug delivery toward the cell membrane: Computational Analysis
Recently, Carbon Nano (CN) structures are widely used in medical applications, especially the detection and treatment of cancer disease. Among various types of CNs, Carbone Nano Tubes (CNTs) attracted many researchers' attention to consider them toward clinical application. Regarding the intrinsic structure of CNTs, they can be used widely in drug delivery applications. Functionalized CNTs and ...
متن کاملMathematical Analysis of Drug Release for Gastrointestinal Targeted Delivery Using β-Lactoglobulin Nanoparticle
To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...
متن کاملDesign and Construction of Ph-Sensitive Drug Delivery System Based on Metal-Organic Framework (MOF) Nanoparticles for Cancer Treatment by Drug Delivery System Containing Curcumin
Introduction: Much research has been carried out to improve drug delivery and targeted drug delivery to the body in order to minimize side effects, provide controlled delivery of the drug to the desired location and to achieve optimal therapeutic effects. Zeolitic imidazolate-8 (ZIF-8) is a subset of MOFs that are biocompatible, stable in the aquatic environment and have adjustable porosity. In...
متن کاملEngineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors
BACKGROUND Lentiviral vectors with broad tropism are one of the most promising gene delivery systems capable of efficiently delivering genes of interest into both dividing and non-dividing cells while maintaining long-term transgene expression. However, there are needs for developing lentiviral vectors with the capability to deliver genes to specific cell types, thus reducing the "off-target" e...
متن کاملLentiviral vectors: basic to translational.
More than two decades have passed since genetically modified HIV was used for gene delivery. Through continuous improvements these early marker gene-carrying HIVs have evolved into safer and more effective lentiviral vectors. Lentiviral vectors offer several attractive properties as gene-delivery vehicles, including: (i) sustained gene delivery through stable vector integration into host genome...
متن کامل